Previous issue | Next issue | Archive

Volume 13 (4); December 25, 2023

Research Paper 

Analysis of risk factors and outcomes of acute kidney injury in young children after cardiac surgery

Ismailov SI, Khaydarov AE, Mamasiddikov SM, Narziev MZh, Khamraev GM, Nosirov RN, Sobirov DM, and Mardonov ZhN.

J. Life Sci. Biomed., 13(4): 59-65, 2023; pii:S225199392300009-13

DOI: https://dx.doi.org/10.54203/jlsb.2023.9 

Abstract

The aim of this study was to analysis of risk factors and outcomes of acute kidney injury (AKI) in young children with congenital heart disease (CHD) after cardiac surgery. The study included 137 young children with CHD after various types of cardiac surgery. The stages of AKI and indications for peritoneal dialysis (PD) were determined based of Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. The incidence of AKI in young children in the general group was 40.9% (n=56). Stage 1 AKI was diagnosed in 21.9% (n=29) of patients, stage 2 AKI in 12.4% (n=17), and stage 3 AKI in 7.3% (n=10) of patients. Peritoneal dialysis was performed in 11.7% (n=16) of children. The incidence of AKI development after radical correct transposition of the great vessels (TGV) was 55.5% (n=5), truncus arteriosus (TA) was 100%, pulmonary atresia (PA)=25%, tetralogy of Fallot (TF)=38.1%, total anomalous pulmonary vein drainage (TAPVD)=60%, partial anomalous pulmonary vein drainage (PAPVD)=37.5%, atrioventricular canal (AVC)=44.4%, double outlet of main vessels from the right ventricle (DOMV from the RV)=60% , interventricular septal defect with high pulmonary hypertension (VSD)=21.6%, and combined operations was 46.6%. The need for PD after TGV correction was 22.2% (n=2), after TA=100%, after TF=33.3%, after TAPVD=20%, after AVC=11.1%, after VSD=1.9%, and after combined operations was 13.3%. Risk factors for AKI in young children were: younger age, initial heart failure, type of operation, prolonged cardiopulmonary bypass (CPB) and aortic clamping (AC), low cardiac output syndrome, inotropic and vasopressor therapy, hyperlactatemia. The development of AKI led to increased length of stay in the intensive care unit, overall hospitalization and infant mortality.
Keywords: Acute kidney injury, Children, Risk factors, AKI outcomes, Peritoneal dialysis.

[Full text-PDF] [ePub] [Export citation from ePrint] [How to Cite]

Previous issue | Next issue | Archive

This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0)